Cardioplegia solutions have been used for myocardial protection in cardiac surgery for decades. Different cardioplegic strategies have been evaluated. Del Nido
del Nido Cardioplegia Solution 1000 mL (IV Bags) Open configuration options This item is packaged with 4 pre-filled 1000mL IV Bags per case.
It was primarily designed for children and it has been used in pediatric cardiac surgery in Boston's Children Hospital since 1994. There are few studies regarding the del Nido cardioplegia. OBJECTIVES: Del Nido cardioplegia is a non-glucose-based solution given as a single dose that provides up to 180 minutes of cardiac quiescence. The del Nido solution (DNS) has been used safely for nearly two decades at a single center in both pediatric and adult patients.
The trend of troponin concentration suggests that del Nido cardioplegia has a better myocardial protective effect. Blood cardioplegia (BC), which is the mixture of the subject's oxygenated blood (80%) and a crystalloid solution (20%), is the most widely used cardioplegia type [ 1]. The del Nido solution was formulated by researchers from the University of Pittsburgh (Pittsburgh, PA, USA) in the early 1990s [ 5]. The del Nido cardioplegia (DNC), a non-glucose-based and calcium-free solution (four-parts crystalloid to one part whole blood), is a simple and cost-effective formulation that has been safely employed for decades in paediatric patients. 6, 7 It is generally used in a single-dose fashion (usually limited to 1000 ml) and subsequent doses are not necessary, except for extraordinarily long cross-clamp times (more than 2.5-3.0 hours).
The convenience offered by a single-dose cardioplegia strategy is the avoidance of interruption of the flow of surgery and, more importantly, a significant reduction in the cross-clamp time.
Del Nido cardioplegia: from an infant conceive to an adult life - a brief review of the current evidence in adult patients Claudio Pragliola 1,2, Essam Hassan1,3, Abdulaziz Al Hossan 1, Khaled Al Otaibi 1, Juan J. T. Alfonso , Afnan Al Khalaf1, Khalid D. Al Garni1,4 1Prince Sultan Military Cardiac Centre, Riyadh 11564, Saudi Arabia.
Apesar disso, em pacientes com baixa fração de ejeção, disfunção ventricular direita, cirurgias combinadas ou com tempo de clampeamento aórtico estimado alto, é preferível ainda o uso de cardioplegia convencional, por ainda não haver grande base na literatura confirmando KEYWORDS : cardioplegia, del Nido, In the early 1990s del Nido cardioplegia was developed by Pedro del Nido, Hung Cao-Danh, Eric Sommers and Akihiko Ohkado at the university of Pittsburgh for pediatric and infant cardiac surgeries. Its use in adult cardiac surgeries is expanding now.
Del Nido cardioplegia is a safe and effective method of myocardial protection in adult cardiac surgery. It allows for longer redosing interval with safety profile and mortality comparable to cold blood cardioplegia as exemplified by lower troponin T release when corrected for the time of myocardial ischemia.
Cardiovascular Agents. Heart Valve Prosthesis. DOI: 10.21470/1678-9741-2020-0063 Del Nido (DN) cardioplegia, a calcium-free, hyperkalemic solution containing lidocaine and magnesium has been developed to help reduce intracellular calcium influx and the resulting myocyte damage in the immediate postischemic period following cardiac arrest. DN cardioplegia has been used for pediatric cardiac surgery but its use in complex reoperative surgery has not been studied.
Del Nido cardioplegia Del Nido cardioplegia was developed by Pedro Del Nido and his team at the University of Pittsburgh in 1990s. It has been used for pediatric cardiac surgery in Boston’s Children Hospital since 1994 and, since 2003, it has been successfully used for adult cardiac surgery as well [8]. 2016-12-30
Del Nido vs. Buckberg Cardioplegia in Adult Isolated Valve Surgery Stephanie L Mick, Michael Robich, Catherine Torma, Annmarie Fatula, Patrick Grady, A. Marc Gillinov, Edward Soltesz, Douglas R Johnston, Joseph F Sabik, III Cleveland Clinic, Cleveland, OH. OBJECTIVES: Del Nido cardioplegia is a non-glucose-based solution given as a single dose that provides up to 180 minutes of cardiac quiescence. Matte GS, del Nido PJ. History and use of del Nido cardioplegia solution at Boston Children's Hospital.
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In the 16 Nov 2020 References (52) [4] Del Nido is a crystalloid-based cardioplegia known to have a prolonged arrest time due to the lignocaine and magnesium 14 Jul 2020 The del Nido cardioplegia solution (DNS) was first formulated for pediatric cardiac surgery in the early 1990s and has been widely used ever 18 Sep 2019 Del Nido cardioplegia was initially used in pediatric patients and has been expanding into adult cardiac centers over the last decade. It can be Recovery after 60 minutes of cardioplegic arrest was assessed in isolated working senescent rat hearts. Del Nido cardioplegia was delivered as a single dose (n ¼ The del Nido. (dN) cardioplegia solution, the most commonly used cardioplegia, developed with some of the above- mentioned specific focus, is used by a third of 8 Oct 2020 A novel single‐dose BC that can provide an extended period of safe myocardial ischemic arrest was developed by Matte and del Nido and was Key Words: cardioplegia; del Nido; depolarized arrest; myocardial protection; cardiac surgery; adults. AS ANESTHESIOLOGISTS constantly balance the needs .
Commonly referred to as ‘‘del Nido solution,’’ this blood and crystalloid
Del Nido cardioplegia solution has been our preferred agent for myocardial protection. Del Nido consists of a hyperkalemic, hypocalcemic Plegisol solution with lidocaine and magnesium additives (Plegisol; Abbott Laboratories, Chicago, IL) (Table 1). 2021-01-13 · DNC is a cold blood cardioplegia modified with a higher level of potassium. It was initially developed by Professor Pedro Del Nido at the University of Pittsburgh given the use in children's immature myocardium [ 3 ].
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11 Dec 2019 Dr. Pedro del Nido (dN) developed a cardioplegic solution, especially for the myocardial protection in neonatal and pediatric cardiac surgery
Different cardioplegic strategies have been evaluated. Del Nido cardioplegia was initially used in pediatric patients and has been expanding into adult cardiac centers over the last decade. Del Nido cardioplegia is routinely used in clinical practice both in paediatric and adult population in high volume centres. It could be a safe, effective and cheap myocardial protection strategy of universal implementation in cardiac surgery. Additional prospective studies are needed to confirm these data.